Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep;29(9):965-992.
doi: 10.1002/pds.4966. Epub 2020 May 19.

Interventions to improve adverse drug reaction reporting: A scoping review

Malahat Khalili  1 , Bita Mesgarpour  2 , Hamid Sharifi  1 , Samira Daneshvar Dehnavi  3 , Ali Akbar Haghdoost  1
Affiliations

Interventions to improve adverse drug reaction reporting: A scoping review

Malahat Khalili et al. Pharmacoepidemiol Drug Saf. 2020 Sep.

Abstract

Purpose: Underreporting is the major limitation of a voluntary adverse drug reaction (ADR) reporting system. Many studies have assessed the effectiveness of different interventions designed to improve ADR reporting. The aim of this study was to systematically map interventions and strategies to improve ADR reporting among health care professionals.

Methods: The six-stage methodological framework of Arksey and O'Malley was used to conduct this scoping review. Ovid MEDLINE, EMBASE, All EBM, and Web of Science were systematically searched from 1999 to February 2019, and the reference lists of the included papers were also searched for gray literature to identify any interventions and strategies that aimed to increase ADR reporting. Two reviewers screened the papers for eligibility based on the inclusion criteria and extracted their key data and analyzed them descriptively.

Results: Ninety out of 14 501 papers met the selection criteria. Using computerized registration and active surveillance can increase ADR reporting significantly. Educational interventions performed individually or combined with sending reminders and/or feedback, awards, and providing easier reporting channels can improve ADR reporting over a short to medium term. Multiple interventions may have more impact than single-component interventions.

Conclusion: Multiple interventions could cause a greater increase in ADR reporting rates than single interventions. Although educational interventions appear to be effective, few studies have reviewed their long-term effects to ascertain whether the improvements are sustained over time. Studies with a better methodological quality are required on this subject.

Keywords: adverse drug reaction; adverse drug reaction reporting systems; pharmacoepidemiology; pharmacovigilance.

PubMed Disclaimer

References

REFERENCES

    1. Fang H, Lin X, Zhang J, et al. Multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in China. BMC Pharmacol Toxicol. 2017;18(1):49.
    1. Ribeiro-Vaz I, Herdeiro MT, Polónia J, Figueiras A. Strategies to increase the sensitivity of pharmacovigilance in Portugal. Rev Saude Publica. 2011;45(1):129-135.
    1. Lapatto Reiniluoto O, Patinen L, Niemi M, Backman JT, Neuvonen PJ. Drug related inadvertent deaths in a university hospital-a declining trend. Basic Clin Pharmacol Toxicol. 2015;117(6):421-426.
    1. Carrasco-Garrido P, de Andrés LA, Barrera VH, de Miguel GÁ, Jiménez-García R. Trends of adverse drug reactions related-hospitalizations in Spain (2001-2006). BMC Health Serv Res. 2010;10(1):287.
    1. Mouton JP, Njuguna C, Kramer N, et al. Adverse drug reactions causing admission to medical wards: a cross-sectional survey at 4 hospitals in South Africa. Medicine. 2016;95(19):e3437-e3437.

Publication types

MeSH terms

LinkOut - more resources