Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun 16;323(23):2427-2429.
doi: 10.1001/jama.2020.8707.

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

Supinda Bunyavanich  1 , Anh Do  2 , Alfin Vicencio  1
Affiliations

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

Supinda Bunyavanich et al. JAMA. .

Abstract

This study compares angiotensin-converting enzyme 2 (ACE2) gene expression, which has been associated with SARS-CoV-2 cell entry, in the nasal epithelium of children vs adults.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: Dr Vicencio reported being an investor in Filament Biosolutions. No other disclosures were reported.

Figures

Figure.
Figure.. Nasal Gene Expression of ACE2 in Different Age Groups
Data are means (data points) and 95% confidence intervals (error bars) for angiotensin-converting enzyme 2 (ACE2) gene expression in younger children (aged <10 years), older children (aged 10-17 years), young adults (aged 18-24 years), and adults (aged ≥25 years). Gene counts are shown as logarithmic (log2) counts per million. P values are from linear regression modeling in which ACE2 gene expression in log2 counts per million was the dependent variable and age group was the independent variable.
See this image and copyright information in PMC

Comment in

References

    1. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239-1242. doi:10.1001/jama.2020.2648 - DOI - PubMed
    1. CDC COVID-19 Response Team Coronavirus disease 2019 in children—United States, February 12–April 2, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(14):422-426. doi:10.15585/mmwr.mm6914e4 - DOI - PMC - PubMed
    1. Dong Y, Mo X, Hu Y, et al. . Epidemiology of COVID-19 among children in China. Pediatrics. 2020;145(4):e20200702. doi:10.1542/peds.2020-0702 - DOI - PubMed
    1. Hoffmann M, Kleine-Weber H, Schroeder S, et al. . SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271-280.e8. doi:10.1016/j.cell.2020.02.052 - DOI - PMC - PubMed
    1. Schouten LR, van Kaam AH, Kohse F, et al. ; MARS Consortium . Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study. Ann Intensive Care. 2019;9(1):55. doi:10.1186/s13613-019-0529-4 - DOI - PMC - PubMed

Publication types

MeSH terms

Substances