Letter: does vitamin D have a potential role against COVID-19?

Abstract

LINKED CONTENT

This article is linked to Tian et al and Tian and Rong papers. To view these articles, visit https://doi.org/10.1111/apt.15731 and https://doi.org/10.1111/apt.15817.

FIGURE 1

The role of vitamin D in COVID‐19. SARS‐CoV‐2 binds to the ACE2 of alveolar cells and disturbs the ratio of ACE2/ACE activity. It increases ACE activity and, in turn, results in more angiotensin II formation causing pulmonary vasoconstriction to precipitate severe COVID19. Vitamin D induces ACE2 expression, which limits the formation of angiotensin II via ACE and reduces lung injury. Besides, vitamin D also acts on renin and inhibits its activity, which further contributes to the reduction in angiotensin II. Therefore, vitamin D supplementation may have a protective role against COVID‐19. (Dotted line indicates indirect effect)