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Review
. 2020 Apr 30;13(4):dmm043448.
doi: 10.1242/dmm.043448.

Membrane trafficking in health and disease

Rebecca Yarwood  1 , John Hellicar  1 , Philip G Woodman  2 , Martin Lowe  2
Affiliations
Review

Membrane trafficking in health and disease

Rebecca Yarwood et al. Dis Model Mech. .

Abstract

Membrane trafficking pathways are essential for the viability and growth of cells, and play a major role in the interaction of cells with their environment. In this At a Glance article and accompanying poster, we outline the major cellular trafficking pathways and discuss how defects in the function of the molecular machinery that mediates this transport lead to various diseases in humans. We also briefly discuss possible therapeutic approaches that may be used in the future treatment of trafficking-based disorders.

Keywords: Disease; Endocytic pathway; Genetic disorder; Membrane traffic; Secretory pathway; Vesicle.

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Conflict of interest statement

Competing interestsThe authors declare no competing or financial interests.

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