Important Interactions of Immunosuppressants With Experimental Therapies for Novel Coronavirus Disease (COVID-19): How to Act

Affiliations

¹ Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.
² Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.
³ UMC Groningen Comprehensive Transplant Center, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.

Comment

Tanja R Zijp et al. Ther Drug Monit. 2020 Aug.

. 2020 Aug;42(4):652-653.

doi: 10.1097/FTD.0000000000000766.

¹ Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.
² Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.
³ UMC Groningen Comprehensive Transplant Center, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.

No abstract available

Comment on

A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.
Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, Ruan L, Song B, Cai Y, Wei M, Li X, Xia J, Chen N, Xiang J, Yu T, Bai T, Xie X, Zhang L, Li C, Yuan Y, Chen H, Li H, Huang H, Tu S, Gong F, Liu Y, Wei Y, Dong C, Zhou F, Gu X, Xu J, Liu Z, Zhang Y, Li H, Shang L, Wang K, Li K, Zhou X, Dong X, Qu Z, Lu S, Hu X, Ruan S, Luo S, Wu J, Peng L, Cheng F, Pan L, Zou J, Jia C, Wang J, Liu X, Wang S, Wu X, Ge Q, He J, Zhan H, Qiu F, Guo L, Huang C, Jaki T, Hayden FG, Horby PW, Zhang D, Wang C. Cao B, et al. N Engl J Med. 2020 May 7;382(19):1787-1799. doi: 10.1056/NEJMoa2001282. Epub 2020 Mar 18. N Engl J Med. 2020. PMID: 32187464 Free PMC article. Clinical Trial.

1. Cao B, Wang Y, Wen D, et al. A trial of lopinavir–ritonavir in adults hospitalized with severe covid-19. N Engl J Med. 2020.
1. Badri P, Dutta S, Coakley E, et al. Pharmacokinetics and dose recommendations for cyclosporine and tacrolimus when coadministered with ABT-450, ombitasvir, and dasabuvir. Am J Transpl. 2015;15:1313–1322.
1. Yilmaz M, Gökengin D, Bozbiyik O, et al. Kidney transplant in a human immunodeficiency virus-positive patient: case report of drug interactions. Exp Clin Transpl. 2017. doi: 10.6002/ect.2017.0013. - DOI
1. Badri PS, Parikh A, Coakley EP, et al. Pharmacokinetics of tacrolimus and cyclosporine in liver transplant recipients receiving 3 direct-acting antivirals as treatment for hepatitis C infection. Ther Drug Monit. 2016;38:640–645.
1. Floren LC, Christians U, Zimmerman JJ, et al. Sirolimus oral bioavailability increases ten-fold with concomitant ketoconazole. Clin Pharmacol Ther. 1999;65:159.