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. 2020 May 19;52(5):724-726.
doi: 10.1016/j.immuni.2020.04.019.

Charting the Roadmap of T Cell Exhaustion

Talyn Chu  1 , Dietmar Zehn  2
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Charting the Roadmap of T Cell Exhaustion

Talyn Chu et al. Immunity. .
Free article

Abstract

Exposure to chronic infection or malignant tumors triggers the differentiation of functionally impaired, so-called exhausted T cells. In this issue of Immunity, Beltra et al. reveal a multi-step developmental process that defines how T cells transition from proliferating progenitors into terminally differentiated exhausted T cells.

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