Comment
doi: 10.1016/j.immuni.2020.04.013.
T-bet+ Memory B Cells Stay in Place
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- PMID: 32433944
- DOI: 10.1016/j.immuni.2020.04.013
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T-bet+ Memory B Cells Stay in Place
Immunity.
.
Free article
Abstract
Memory B cells (MBCs) expressing the transcription factor T-bet have been described in normal and dysregulated immune responses. In this issue of Immunity, Johnson et al. report that T-bet+ MBCs, formed in response to a primary influenza infection, contribute to protective antibody titers and persist mainly in the spleen with restricted trafficking between tissues.
Published by Elsevier Inc.
Comment on
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The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans.Immunity. 2020 May 19;52(5):842-855.e6. doi: 10.1016/j.immuni.2020.03.020. Epub 2020 Apr 29. Immunity. 2020. PMID: 32353250 Free PMC article.
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