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Case Reports
. 2020 May 20;7(4):e756.
doi: 10.1212/NXI.0000000000000756. Print 2020 Jul.

Sequential interleukin 2 and pembrolizumab use in progressive multifocal leukoencephalopathy

Christoph Mahler  1 , Michael Andrews  1 , Sian M Henson  1 , Sharmilee Gnanapavan  2
Affiliations
Case Reports

Sequential interleukin 2 and pembrolizumab use in progressive multifocal leukoencephalopathy

Christoph Mahler et al. Neurol Neuroimmunol Neuroinflamm. .
No abstract available

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Figures

Figure
Figure. Antiviral immune response and PML lesion evolution after treatment with IL2 and pembrolizumab for case 1 and 2
Shown is the percentage of PD-1+ in CD4+ and CD8+ T-cells in blood and the JC virus DNA titer in CSF (A and B) and lymphocyte subpopulations in blood (case 1: A, case 2: B) (C) case 2 PD-1+ % in blood vs age-matched control (control PD-1+) and JC virus DNA titer in the CSF. Evolution of the PML lesion in MRI (D) case 1, (E) case 2, top: T2/FLAIR, middle: T2/FLAIR lesion area pseudocolored in yellow, differential increase (red), differential reduction (green), bottom: B1000 DWI. Treatment bar: brown for IL2 and yellow for PD1. *Marks drop in lymphocyte subpopulations in case 2 secondary to dose escalation of IL-2 to 2.07 million units/m2. JC = John Cunningham; PD-1 = programmed cell death protein-1; PML = Progressive multifocal leukoencephalopathy.
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