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. 2020 Mar;24(3):155-159.
doi: 10.5005/jp-journals-10071-23369.

Paraquat Poisoning: A Retrospective Study of 55 Patients From a Tertiary Care Center in Southern India

R Ravichandran  1 , Deepak Amalnath  1 , Kusa K Shaha  2 , B H Srinivas  3
Affiliations

Paraquat Poisoning: A Retrospective Study of 55 Patients From a Tertiary Care Center in Southern India

R Ravichandran et al. Indian J Crit Care Med. 2020 Mar.

Abstract

Background: In India the data on paraquat (PQ) poisoning are limited to case reports and small case series. Hence, this study was carried out to understand the clinical features and outcomes of PQ poisoning. We also briefly report the relevant Indian studies on PQ poisoning.

Materials and methods: This was a retrospective case record-based study of PQ poisoning victims admitted over a period of 5 years.

Results: Of the 55 patients included in this study, the in-hospital mortality rate was 72.7%. Acute kidney injury was the most common manifestation. The use of cyclophosphamide did not affect the clinical outcome. Hemoperfusion (HP) was not done for any patient. Pulmonary edema and acute tubular necrosis were the most common histopathological findings.

Conclusion: In India, this is one of the most comprehensive studies of PQ toxicity. Hence, we hope that this information would be of use to clinicians who deal with PQ poisoning.

How to cite this article: Ravichandran R, Amalnath D, Shaha KK, Srinivas BH. Paraquat Poisoning: A Retrospective Study of 55 Patients from a Tertiary Care Center in Southern India. Indian J Crit Care Med 2020;24(3):155-159.

Keywords: Paraquat; Paraquat poisoning; Toxicology.

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Conflict of interest statement

Source of support: Nil Conflict of interest: None

Figures

Figs 1A to D
Figs 1A to D
Histopathological sections from (A) Lung shows congestion and alveolar hemorrhage (H&E × 40); (B) Kidney shows evidence of congestion in glomerular and interstitial capillaries with mild acute tubular necrosis (H&E × 100); (C and D) Liver shows intracytoplasmic and intracanalicular cholestasis (arrow) and microvesicular steatosis (arrow head) (H&E × 100)
See this image and copyright information in PMC

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