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Review
. 2020;26(2):955-968.
doi: 10.1007/s10989-019-09899-z. Epub 2019 Jul 22.

Plant-Derived Bioactive Peptides: A Treatment to Cure Diabetes

Shital P Patil  1 , Ashutosh Goswami  1 , Kiran Kalia  2 , Abhijeet S Kate  1
Affiliations
Review

Plant-Derived Bioactive Peptides: A Treatment to Cure Diabetes

Shital P Patil et al. Int J Pept Res Ther. 2020.

Abstract

Abstract: Recent advances in analytical techniques have opened new opportunities for plant-based drug discovery in the field of peptide and proteins. Enzymatic hydrolysis of plant parent proteins forms bioactive peptides which are explored in the treatment of various diseases. In this review, we will discuss the identified plant-based bioactive proteins and peptides and the in vitro, in vivo results for the treatment of diabetes. Extraction, isolation, characterization and commercial utilization of plant proteins is a challenge for the pharmaceutical industry as plants contain several interfering secondary metabolites. The market of peptide drugs for the treatment of diabetes is growing at a fast rate. Plant-based bioactive peptides might open up new opportunities to discover economic lead for the management of various diseases.

Keywords: Antidiabetic activity; Bioactive peptides; Plants; Proteins; Seeds.

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Conflict of interest statement

Conflict of interestThe authors declare there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Uses of therapeutic peptides and proteins in various disease conditions (Loganathan 2016)
Fig. 2
Fig. 2
Epidemiology of diabetes country wise (2017a)
Fig. 3
Fig. 3
The general scheme of isolation, purification, and characterization of plant peptides (Gomathi and Subramanian ; Krishnan and Rupp ; Sinz et al. ; Wysocki et al. 2005)
See this image and copyright information in PMC

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