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. 1988 Nov;3(4):342-6.
doi: 10.1016/0888-7543(88)90125-5.

A mapped set of DNA markers for human chromosome 15

Y Nakamura  1 , M Lathrop, P O'Connell, M Leppert, J M Lalouel, R White
Affiliations

A mapped set of DNA markers for human chromosome 15

Y Nakamura et al. Genomics. 1988 Nov.

Abstract

A primary genetic linkage map for human chromosome 15 has been constructed from 16 arbitrary DNA markers genotyped in 59 large reference families. The map spans a genetic distance of 146 cM in males and 187 cM in females. The ratio of female/male genetic distance was approximately 2.1 overall within the region of the chromosome covered by our map, but three segments showed a significant male excess in recombination frequency. A subset of seven of the linked markers would be enough to detect linkage of a genetic defect within the mapped region of chromosome 15, if at least 48 phase-known meioses in affected families were available for analysis.

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