Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020;7(1):12-17.
doi: 10.1007/s40472-019-00257-y. Epub 2019 Dec 17.

Heart Retransplantation: Candidacy, Outcomes, and Management

Maya H Barghash  1   2 , Sean P Pinney  1   2
Affiliations
Review

Heart Retransplantation: Candidacy, Outcomes, and Management

Maya H Barghash et al. Curr Transplant Rep. 2020.

Abstract

Purpose of review: To describe the incidence and epidemiology of heart retransplantation in adults and children and to review the risk factors associated with adverse outcome following retransplantation to help guide recipient selection.

Recent findings: Heart retransplantation is associated with inferior short-term and long-term survival when compared with primary heart transplantation and its use remains controversial although less so in the pediatric heart transplant population.

Summary: In the most recent era of heart transplantation, patients retransplanted for CAV, greater than 1 year from their primary transplant, and who are not in critical condition have improved survival compared with other retransplant recipients. Survival with retransplantation can approach that of primary transplantation when patients are appropriately selected. More research is needed regarding the optimal timing for retransplantation and the optimal management for patients after retransplantation.

Keywords: Advanced heart failure; Heart transplant; Retransplantation.

PubMed Disclaimer

Conflict of interest statement

Conflict of InterestMaya Barghash declares no conflict of interest. Sean Pinney reports personal fees from Abbott Inc, Alnylam Inc., Medtronic Inc., and Procyrion Inc., outside the submitted work.

Figures

Fig. 1
Fig. 1
Survival in adult heart retransplantation stratified by indication. a Kaplan-Meier 1-year survival, b long-term survival, and c long-term survival conditional on survival to 1 year by diagnosis (indication for retransplantation) for adult heart retransplants (1982–June 2012). CAV, cardiac allograft vasculopathy. Used with permission from the International Society for Heart and Lung Transplantation [•]
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Khush KK, et al. for the International Society for Heart and Lung Transplantation. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation (ISHLT): thirty-fifth Adult Heart and Lung Transplantation Report – 2018; Focus Theme: Multiorgan Transplantation. JHLT. 2018;30(10):1155–1168. - PubMed
    1. • Lund LH et al. for the International Society of Heart and Lung Transplantation. The registry of the International Society for Heart and Lung Transplantation: thirty-first official adult heart transplant report – 2014; focus theme: Retransplantation. JHLT 2014; 33(10): 996-1008. This ISHLT report from the international registry focused on providing data on adult heart retransplantation. - PubMed
    1. Srivastava Rohit, Keck Berkeley M., Bennett Leah E., Hosenpud Jeffrey D. THE RESULTS OF CARDIAC RETRANSPLANTATION: AN ANALYSIS OF THE JOINT INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION/UNITED NETWORK FOR ORGAN SHARING THORACIC REGISTRY. Transplantation. 2000;70(4):606–612. doi: 10.1097/00007890-200008270-00013. - DOI - PubMed
    1. Costanzo MR, Naftel DC, Pritzker MR, Heilman JK, Boehmer JP, Brozena SC, et al. Heart transplant coronary artery disease detected by coronary angiography: a multiinstitutional study of preoperative donor and recipient risk factors. Cardiac transplant research database. J Heart Lung Transplant. 1998;17:744–75. - PubMed
    1. Mehra Mandeep R., Crespo-Leiro Maria G., Dipchand Anne, Ensminger Stephan M., Hiemann Nicola E., Kobashigawa Jon A., Madsen Joren, Parameshwar Jayan, Starling Randall C., Uber Patricia A. International Society for Heart and Lung Transplantation working formulation of a standardized nomenclature for cardiac allograft vasculopathy—2010. The Journal of Heart and Lung Transplantation. 2010;29(7):717–727. doi: 10.1016/j.healun.2010.05.017. - DOI - PubMed

LinkOut - more resources