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Review
. 2020;7(2):31-37.
doi: 10.1007/s40472-020-00274-2. Epub 2020 Mar 26.

Cognitive Function in Liver Transplantation

Somaya A M Albhaisi  1 , Jasmohan S Bajaj  2
Affiliations
Review

Cognitive Function in Liver Transplantation

Somaya A M Albhaisi et al. Curr Transplant Rep. 2020.

Abstract

Purpose of review: Liver transplantation (LT) remains the only way to cure patients with severe liver diseases. Important questions about neurological sequelae and quality of life after LT have emerged. In this review, we discuss the neurocognitive changes associated with LT and we conclude with recommendations in this regard for patients, caregivers, and physicians.

Recent findings: Compared with other solid organ recipients, LT patients tend to have a higher incidence (up to 30%) of neurological complications post-LT. Even in absence of previous episodes of hepatic encephalopathy (HE), some patients display new onset of neurological symptoms post-LT, raising the concern about the role of other factors that may have a direct impact on cognitive function.

Summary: Different mechanisms have been postulated to explain these postoperative neurological symptoms. They include sequelae of HE, persistent impairment of cognitive function due to cirrhosis, or postoperative decompensation of an unknown or undiagnosed neurodegenerative disorder.

Keywords: Brain function; Cirrhosis; Cognition; Cognitive reserve; Transplant.

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Conflict of interest statement

Conflict of InterestDr. Albhaisi has no conflict of interest. Dr. Bajaj has served on Advisory boards for Norgine and Merz and his institution received research grants from Grifols and Valeant Pharmaceuticals.

Figures

Fig. 1
Fig. 1
Factors that affect the cognitive function before and after liver transplant
See this image and copyright information in PMC

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