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. 2020 Dec 15;71(12):3232-3236.
doi: 10.1093/cid/ciaa623.

Connecting Hydroxychloroquine In Vitro Antiviral Activity to In Vivo Concentration for Prediction of Antiviral Effect: A Critical Step in Treating Patients With Coronavirus Disease 2019

Jianghong Fan  1 , Xinyuan Zhang  1 , Jiang Liu  1 , Yuching Yang  1 , Nan Zheng  1 , Qi Liu  2 , Kimberly Bergman  2 , Kellie Reynolds  3 , Shiew-Mei Huang  2 , Hao Zhu  1 , Yaning Wang  1
Affiliations

Connecting Hydroxychloroquine In Vitro Antiviral Activity to In Vivo Concentration for Prediction of Antiviral Effect: A Critical Step in Treating Patients With Coronavirus Disease 2019

Jianghong Fan et al. Clin Infect Dis. .

Abstract

Translation of in vitro antiviral activity to the in vivo setting is crucial to identify potentially effective dosing regimens of hydroxychloroquine. In vitro 50%/90% maximal effective concentration values for hydroxychloroquine should be compared to the in vivo free extracellular tissue concentration, which is similar to the free plasma hydroxychloroquine concentration.

Keywords: COVID-19; SARS-CoV-2; antiviral activity; hydroxychloroquine.

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