To Interpret the SARS-CoV-2 Test, Consider the Cycle Threshold Value

Michael R Tom¹, Michael J Mina^{2

3

4}

Affiliations

¹ Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, Massachusetts, USA.
² Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
³ Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
⁴ Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Comment

Michael R Tom et al. Clin Infect Dis. 2020.

. 2020 Nov 19;71(16):2252-2254.

doi: 10.1093/cid/ciaa619.

Michael R Tom¹, Michael J Mina^{2

3

4}

¹ Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, Massachusetts, USA.
² Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
³ Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
⁴ Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

No abstract available

Keywords: COVID-19; RT-PCR; SARS-CoV-2; test; viral shedding.

Comment in

Caveats of Reporting Cycle Threshold Values from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Qualitative Polymerase Chain Reaction Assays: A Molecular Diagnostic Laboratory Perspective.
Poon KS, Wen-Sim Tee N. Poon KS, et al. Clin Infect Dis. 2021 Nov 2;73(9):e2851-e2852. doi: 10.1093/cid/ciaa1399. Clin Infect Dis. 2021. PMID: 32929464 Free PMC article. No abstract available.
Optimal Cycle Thresholds for Coronavirus Disease 2019 (COVID-19) Screening-Receiver Operating Characteristic (ROC)-Based Methods Highlight Between-Study Differences.
Hirschfeld G, von Glischinski M, Thiele C. Hirschfeld G, et al. Clin Infect Dis. 2021 Aug 2;73(3):e852-e853. doi: 10.1093/cid/ciaa1883. Clin Infect Dis. 2021. PMID: 33354720 Free PMC article. No abstract available.

Profile of RT-PCR for SARS-CoV-2: A Preliminary Study From 56 COVID-19 Patients.
Xiao AT, Tong YX, Zhang S. Xiao AT, et al. Clin Infect Dis. 2020 Nov 19;71(16):2249-2251. doi: 10.1093/cid/ciaa460. Clin Infect Dis. 2020. PMID: 32306036 Free PMC article.