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. 2020 May 20;10(1):61.
doi: 10.1186/s13613-020-00681-9.

Nitric oxide inhalation as an interventional rescue therapy for COVID-19-induced acute respiratory distress syndrome

Jun Kobayashi  1 , Isamu Murata  2
Affiliations

Nitric oxide inhalation as an interventional rescue therapy for COVID-19-induced acute respiratory distress syndrome

Jun Kobayashi et al. Ann Intensive Care. .

Abstract

COVID-19 is an emerging disease of public health concern. While there is no specific recommended treatment for COVID-19, nitric oxide has the potential to be of therapeutic value for managing acute respiratory distress syndrome in patients with COVID-19. However, inhaled nitric oxide has not yet been formally evaluated. Given the extent of the COVID-19 pandemic, and the large numbers of hospitalized patients requiring respiratory support, clinical use of inhaled nitric oxide may become an alternate rescue therapy before extracorporeal membrane oxygenation for the management of acute respiratory distress syndrome in patients with COVID-19.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. Li L, Li R, Wu Z, Yang X, Zhao M, Liu J, et al. Therapeutic strategies for critically ill patients with COVID-19. Ann Intensive Care. 2020;10:45. doi: 10.1186/s13613-020-00661-z. - DOI - PMC - PubMed
    1. Chen L, Liu P, Gao H, Sun B, Chao D, Wang F, et al. Inhalation of nitric oxide in the treatment of severe acute respiratory syndrome: a rescue trial in Beijing. Clin Infect Dis. 2004;39(10):1531–1535. doi: 10.1086/425357. - DOI - PMC - PubMed
    1. Nicholls JM, Poon LLM, Lee KC, Ng WF, Lai ST, Leung CY, et al. Lung pathology of fetal severe acute respiratory syndrome. Lancet. 2003;361:1773–1778. doi: 10.1016/S0140-6736(03)13413-7. - DOI - PMC - PubMed
    1. Lei C, Su B, Dong H, Bellavia A, Di Fenza R, Fakhr BS, et al. Protocol of a randomized controlled trial testing inhaled nitric oxide in mechanically ventilated patients with severe acute respiratory syndrome in COVID-19 (SARS-CoV-2) medRxiv. 2020 doi: 10.1101/2020.03.09.20033530. - DOI
    1. McMahon TJ, Doctor A. Extrapulmonary effects of inhaled nitric oxide: role of reversible S-nitrosylation of erythrocytic hemoglobin. Proc Am Thorac Soc. 2006;3(2):153–160. doi: 10.1513/pats.200507-066BG. - DOI - PMC - PubMed