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Review
. 2020 Jun;80(9):859-868.
doi: 10.1007/s40265-020-01322-y.

Novel Approaches Towards a Functional Cure of HIV/AIDS

Lucia Bailon  1   2 , Beatriz Mothe  1   3   4 , Lance Berman  5 , Christian Brander  6   7   8   9
Affiliations
Review

Novel Approaches Towards a Functional Cure of HIV/AIDS

Lucia Bailon et al. Drugs. 2020 Jun.

Erratum in

Abstract

Therapeutic approaches towards a functional cure or eradication of HIV have gained renewed momentum upon encouraging data emerging from studies in SIV monkey models and recent results from human clinical studies. However, a multitude of questions remain to be addressed, including how to deal with the latent viral reservoir, how to boost the host immune response to the virus and what the hurdles are to reach relevant viral compartments in the body. Advances have been made especially with regard to identifying agents that can reactivate the latent virus in vivo and boost the cellular and humoral immunity, but it remains largely unclear whether any of these strategies can awaken a sufficiently large fraction of the viral reservoir and whether the boosted immunity can prevent rapid viral replication once antiretroviral treatments are stopped.

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Conflict of interest statement

The present work was funded in parts by the European Union’s Horizon 2020 research and innovation programme under grant agreement 681137-EAVI2020 and by NIH Grant P01-AI131568. BM is a consultant for AELIX Therapeutics, S.L., outside the submitted work. CB is CSO and shareholder. AELIX Therapeutics, S.L., outside the submitted work. LBe is former CMO of AELIX Therapeutics, S.L. LBa declares no conflicts of interest.

References

    1. UNAIDS. Data 2019. https://www.unaids.org/en/resources/documents/2019/2019-UNAIDS-data. 2019.
    1. Hütter G, Nowak D, Mossner M, Ganepola S, Müßig A, Allers K, Schneider T, Hofmann J, Kütcherer C, Blau O, Hofmann IWK. Long-term control of HIV by stem cell transplantation. N Engl J Med. 2009;360:692–698. - PubMed
    1. Gupta RK, Peppa D, Hill AL, Gálvez C, Salgado M, Pace M, et al. Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report. Lancet HIV. 2020;1(20):1–8. - PMC - PubMed
    1. Dash PK, Kaminski R, Bella R, Su H, Mathews S, Ahooyi TM, et al. Sequential LASER ART and CRISPR treatments eliminate HIV-1 in a subset of infected humanized mice. Nat Commun. 2019;10(1):1–20. - PMC - PubMed
    1. Rasmussen TA, Søgaard OS. Clinical interventions in HIV cure research. Adv Exp Med Biol. 2018;1075:285–318. - PubMed

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