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Comment
. 2020 Jul;25(7):680-682.
doi: 10.1111/resp.13852. Epub 2020 May 20.

The role of SARS-CoV-2 antibodies in COVID-19: Healing in most, harm at times

Affiliations
Comment

The role of SARS-CoV-2 antibodies in COVID-19: Healing in most, harm at times

Martyn A French et al. Respirology. 2020 Jul.
No abstract available

Keywords: COVID-19; antibodies; immunopathology.

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Figures

Figure 1
Figure 1
The antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) are generally neutralizing and the virus is eliminated. However, the antibody response can enhance the inflammatory response through antibody‐dependent enhancement (ADE).

Comment on

References

    1. Giamarellos‐Bourboulis EJ, Netea MG, Rovina N, Akinosoglou K, Antoniadou A, Antonakos N, Damoraki G, Gkavogianni T, Adami M‐E, Katsaounou P et al. Complex immune dysregulation in COVID‐19 patients with severe respiratory failure. Cell Host Microbe 2020; 27: 1–9. - PMC - PubMed
    1. French MA, Tjiam MC, Abudulai LN, Fernandez S. Antiviral functions of human immunodeficiency virus type 1 (HIV‐1)‐specific IgG antibodies: effects of antiretroviral therapy and implications for therapeutic HIV‐1 vaccine design. Front. Immunol. 2017; 8: 780. - PMC - PubMed
    1. Guo L, Ren L, Yang S, Xiao M, Chang D, Yang F, Dela Cruz CS, Wang Y, Wu C, Xiao Y et al. Profiling early humoral response to diagnose novel coronavirus disease (COVID‐19). Clin. Infect. Dis. 2020: ciaa310. 10.1093/cid/ciaa310. - DOI - PMC - PubMed
    1. Zhao J, Yuan Q, Wang H, Liu W, Liao X, Su Y, Wang X, Yuan J, Li T, Li J et al. Antibody responses to SARS‐CoV‐2 in patients of novel coronavirus disease 2019. Clin. Infect. Dis. 2020: ciaa344. 10.1093/cid/ciaa34. - DOI - PMC - PubMed
    1. To KK, Tsang OT, Leung WS, Tam AR, Wu TC, Lung DC, Yip CC, Cai JP, Chan JM, Chik TS et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS‐CoV‐2: an observational cohort study. Lancet Infect. Dis. 2020; 20: 565–74. - PMC - PubMed