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Use of Chloroquine and Hydroxychloroquine in COVID-19 and Cardiovascular Implications: Understanding Safety Discrepancies to Improve Interpretation and Design of Clinical Trials
1 Division of Hematology and Oncology, Mayo Clinic, Rochester, MN (O.O.).
2 Division of Cardiology, Department of Medicine, University of California at Los Angeles (E.H.Y.).
3 Center for Cardiovascular Analytics, Research and Data Science (CARDS), Providence Heart Institute, Providence St Joseph Health, Portland, OR (T.J.G.).
4 The Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (E.D.M., R.S.B.).
5 Department of Cardiovascular Medicine, Mayo Clinic & Mayo Clinic College of Medicine, Rochester, MN (B.J.G.).
Use of Chloroquine and Hydroxychloroquine in COVID-19 and Cardiovascular Implications: Understanding Safety Discrepancies to Improve Interpretation and Design of Clinical Trials
Ohad Oren et al.
Circ Arrhythm Electrophysiol.2020 Jun.
1 Division of Hematology and Oncology, Mayo Clinic, Rochester, MN (O.O.).
2 Division of Cardiology, Department of Medicine, University of California at Los Angeles (E.H.Y.).
3 Center for Cardiovascular Analytics, Research and Data Science (CARDS), Providence Heart Institute, Providence St Joseph Health, Portland, OR (T.J.G.).
4 The Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (E.D.M., R.S.B.).
5 Department of Cardiovascular Medicine, Mayo Clinic & Mayo Clinic College of Medicine, Rochester, MN (B.J.G.).
Dong E, Du H, Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis. 2020;20:533–534. doi: 10.1016/S1473-3099(20)30120-1.
-
PMC
-
PubMed
Rolain JM, Colson P, Raoult D. Recycling of chloroquine and its hydroxyl analogue to face bacterial, fungal and viral infections in the 21st century. Int J Antimicrob Agents. 2007;30:297–308. doi: 10.1016/j.ijantimicag.2007.05.015.
-
PMC
-
PubMed
Sullivan DJ, Jr, Gluzman IY, Russell DG, Goldberg DE. On the molecular mechanism of chloroquine’s antimalarial action. Proc Natl Acad Sci U S A. 1996;93:11865–11870. doi: 10.1073/pnas.93.21.11865.
-
PMC
-
PubMed
Vincent MJ, Bergeron E, Benjannet S, Erickson BR, Rollin PE, Ksiazek TG, Seidah NG, Nichol ST. Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virol J. 2005;2:69. doi: 10.1186/1743-422X-2-69.
-
PMC
-
PubMed
Yao X, Ye F, Zhang M, Cui C, Huang B, Niu P, Liu X, Zhao L, Dong E, Song C, et al. In vitroantiviralactivity and projection of optimizeddosingdesign of hydroxychloroquine for the treatment of severeacuterespiratorysyndromecoronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020:ciaa237. doi: 10.1093/cid/ciaa237.
-
PMC
-
PubMed