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. 2020 May 21;16(5):e1008434.
doi: 10.1371/journal.ppat.1008434. eCollection 2020 May.

A viral journey to the brain: Current considerations and future developments

Nilda Vanesa Ayala-Nunez  1   2 , Raphael Gaudin  1   2
Affiliations

A viral journey to the brain: Current considerations and future developments

Nilda Vanesa Ayala-Nunez et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Ways viruses can use to cross the BBB.
Illustration of a blood vessel and the four nonexclusive ways viruses may employ to reach adjacent tissues: 1. Diffusion (passive-aggressive way): Viruses freely diffuse when endothelium integrity is altered. 2. Infection (energetic way): The endothelium is infected and viruses released on the other side. 3. Transcytosis (commuting way): The circulating virions are endocytosed by endothelial cells and exocytosed on the other side, in the absence of productive infection. 4. Cell transport (Trojan horse way): Leukocytes are carrying the circulating viruses through the endothelial cell wall. BBB, blood–-brain barrier.
See this image and copyright information in PMC

References

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