Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep 15:330:159-166.
doi: 10.1016/j.toxlet.2020.05.005. Epub 2020 May 11.

Short-term perinatal toxicity study in sprague Dawley rats with the plasticizer and emerging contaminant N-Butylbenzenesulfonamide

Cynthia V Rider  1 , Molly Vallant  2 , Chad Blystone  2 , Suramya Waidyanatha  2 , Natalie L South  3 , Guanhua Xie  4 , Katie Turner  5
Affiliations

Short-term perinatal toxicity study in sprague Dawley rats with the plasticizer and emerging contaminant N-Butylbenzenesulfonamide

Cynthia V Rider et al. Toxicol Lett. .

Abstract

N-Butylbenzenesulfonamide (NBBS) is a plasticizer and emerging contaminant that has been detected in a wide array of environmental samples. There are very little toxicity data available with which to evaluate potential risk from exposure to NBBS or other structurally-related sulfonamide plasticizers. To address this knowledge gap, NBBS was selected by the National Toxicology Program for evaluation. The current short-term pre- and post-natal (perinatal) study aims to provide preliminary toxicity and gestational transfer data for NBBS. NBBS was administered via dosed feed at concentrations of 0, 625, 1250, 2500, 5000, and 10,000 ppm to time-mated Sprague Dawley (Hsd:Sprague Dawley SD®) rats from gestation day (GD) 6 through postnatal day (PND) 28. The high concentration of 10,000 ppm NBBS was overtly toxic to dams, and the group was removed on GD 17-18. Exposure to NBBS resulted in lower maternal weights during the gestational period in the 5000 and 10,000 ppm groups as compared to control weights. Dams also displayed lower weights in the lactational period, which resolved to control levels by PND 28. NBBS exposure did not affect pregnancy or littering parameters in F0 dams. However, pup survival was lower in the 5000 ppm group, and pup weights were dose-responsively lower than control pup weights with the difference expanding over the postnatal period. The lowest observed effect level (LOEL) based on significantly lower body weights was 5000 ppm NBBS for F0 dams and 2500 ppm NBBS for F1 pups. Preliminary data for NBBS levels indicated that the chemical was transferred from dams to offspring during the gestational period.

Keywords: Benzosulfonamides; Dose-Range finding study; Gestational transfer; N-butylbenzenesulphonamide.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1.
Figure 1.
Mean body weights of F0 dams during gestation (A) and lactation (B).
Figure 2.
Figure 2.
Male (A) and female (B) pup body weights compared to controls.
See this image and copyright information in PMC

References

    1. Blum KM, Andersson PL, Ahrens L, Wiberg K, Haglund P. (2018). Persistence, mobility and bioavailability of emerging organic contaminants discharged from sewage treatment plants. Sci Total Environ, 612, 1532–42. - PubMed
    1. Di Carro M, Magi E, Massa F, Castellano M, Mirasole C, Tanwar S, Olivari E, Povero P. (2018). Untargeted approach for the evaluation of anthropic impact on the sheltered marine area of Portofino (Italy). Mar Pollut Bull, 131, 87–94. - PubMed
    1. Dunn OJ. (1964). Multiple comparisons using rank sums. Technometrics, 6, 241–52.
    1. Dunnett CW. (1955). A multiple comparison procedure for comparing several treatments with a control. Journal of the American Statistical Association, 50, 1096–121.
    1. Garner CE, Smith S, de Lacy Costello B, White P, Spencer R, Probert CS, Ratcliffe NM. (2007). Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 21, 1675–88. - PubMed

LinkOut - more resources