Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Mar;14(2):281-287.
doi: 10.1055/s-0040-1709924. Epub 2020 May 21.

Effectiveness of Probiotic Lozenges in Periodontal Management of Chronic Periodontitis Patients: Clinical and Immunological Study

Ahmed Alshareef  1 , Alaa Attia  1   2 , Mohammed Almalki  1 , Faisal Alsharif  1 , Ahmed Melibari  1 , Bassel Mirdad  1 , Ehab Azab  1 , Abdel-Rahman Youssef  1   3 , Ahmed Dardir  1   4
Affiliations

Effectiveness of Probiotic Lozenges in Periodontal Management of Chronic Periodontitis Patients: Clinical and Immunological Study

Ahmed Alshareef et al. Eur J Dent. 2020 Mar.

Abstract

Objective: The main purpose of this article was to evaluate the effect of probiotics used as an adjunctive to scaling and root planing (SRP) on the periodontal parameters and matrix metalloproteinase-8 (MMP-8) levels in gingival crevicular fluid (GCF) of chronic periodontitis patients.

Materials and methods: A total of 25 chronic periodontitis patients who completed the treatment course of 40 subjects, aged 25 to 58 years, participated in this study. They were categorized into two groups: the first group was treated by SRP while the second group was treated by SRP and probiotic lozenges twice a day for 30 days. All patients were evaluated clinically by measuring the plaque index, bleeding index (BI), pocket depth, clinical attachment loss, and immunologically by assaying GCF/MMP-8 at baseline and 30 days after periodontal management.

Results: There was a significant improvement in periodontal parameters after SRP treatment with and without probiotic lozenges in both groups. However, there was a significant decrease in the BI (p = 0.05) in SRP and probiotic lozenges group after 30 days compared with SRP alone. In addition, there was a significant decrease in GCF/MMP-8 levels after 30 days in patients managed by SRP only (p = 0.017) compared with the baseline in both groups, whereas a highly significant decrease in patients treated by SRP and probiotics (p = 0.001).

Conclusion: The current study suggested that the probiotics might have a beneficial effect on clinical and immunological outcomes in the management of chronic periodontitis patients. Further research is needed on a large-scale population and for a long recall time to confirm the response to probiotics as an adjunctive to SRP.

PubMed Disclaimer

Conflict of interest statement

None declared.

Figures

Fig. 1
Fig. 1
Demonstration of the mean values of plaque (PI) and bleeding index (BI) in both examined groups.
Fig. 2
Fig. 2
Demonstration of the mean values of pocket depth (PD) and clinical attachment loss (CAL) in both examined groups.
Fig. 3
Fig. 3
Demonstration of the mean values of gingival crevicular fluid/matrix metalloproteinase-8 (GCF/MMP-8) levels (ng/mL) in both investigated groups.
See this image and copyright information in PMC

References

    1. Kornman K S.Mapping the pathogenesis of periodontitis: a new look J Periodontol 20087908(Suppl)1560–1568. - PubMed
    1. Pihlstrom B L, Michalowicz B S, Johnson N W.Periodontal diseases Lancet 2005366(9499)1809–1820. - PubMed
    1. Demmer R T, Papapanou P N. Epidemiologic patterns of chronic and aggressive periodontitis. Periodontol 2000. 2010;53:28–44. - PMC - PubMed
    1. Shaddox L M, Walker C B. Treating chronic periodontitis: current status, challenges, and future directions. Clin Cosmet Investig Dent. 2010;2(02):79–91. - PMC - PubMed
    1. Fermin A. Amsterdam: Elsevier Saunders; 2014. Carranza, Henrry H, Takei. Rationale for periodontal treatment; pp. 404–407, Chap. 34.