Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jul-Aug;13(4):1150-1152.
doi: 10.1016/j.brs.2020.05.012. Epub 2020 May 19.

Can transcranial electrical stimulation motor threshold estimate individualized tDCS doses over the prefrontal cortex? Evidence from reverse-calculation electric field modeling

Kevin A Caulfield  1 , Bashar W Badran  2 , Xingbao Li  2 , Marom Bikson  3 , Mark S George  4
Affiliations

Can transcranial electrical stimulation motor threshold estimate individualized tDCS doses over the prefrontal cortex? Evidence from reverse-calculation electric field modeling

Kevin A Caulfield et al. Brain Stimul. 2020 Jul-Aug.
No abstract available

Keywords: Electric field modeling; Individualized tDCS dosing; Reverse-calculation; Reverse-calculation modeling; Transcranial direct current stimulation; tDCS; tDCS dosing; tDCS modeling.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The City University of New York (CUNY) has IP on neurostimulation system and methods with author Marom Bikson as inventor. Marom Bikson has equity in Soterix Medical Inc and is a consultant for GSK, Halo, and X. We confirm that there are no known conflicts of interest associated with this publication and there was no financial support for this work that could have influenced its outcome.

Figures

Fig. 1.
Fig. 1.. Reverse-Calculation Modeling ROI Analysis Overview and Results.
1A: We used SimNIBS 3.1.1. modeling to place rectangular 70 × 50mm electrodes at F3 (anode) and F4 (cathode). Blue circles depict the spherical 10mm radius ROIs we extracted at the cortical level using grey matter masks. These ROIs were centered around the cortical locations underneath the anode (F3), cathode (F4), and midway between the two electrodes (Fz). 1B: Reverse-Calculation Formula. The individualized dose was determined using one 2mA model and cross-multiplication to determine the individualized dose that would be required to produce the group average electric field. C-E: Prefrontal F3-F4 Reverse-Calculation Dose x TES MT Regressions. We plotted each individual’s reverse-calculation electric field model underneath F3 (1C), F4 (1D), and Fz (1E) against the measured TES MT at the scalp over the motor hotspot. These TES MT values significantly correlated at the ROIs underneath F3 and F4 and trended toward significance for the ROI underneath Fz. With further evaluation and refinement, it appears that TES MT could be a promising candidate technique for individually dosing tDCS without the use of MRI. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
See this image and copyright information in PMC

Comment on

References

    1. Caulfield KA, Badran BW, DeVries WH, Summers PM, Kofmehl E, Li X, et al. Transcranial electrical stimulation motor threshold can estimate individualized tDCS dosage from reverse-calculation electric-field modeling. Brain Stimulation 2020;13. - PMC - PubMed
    1. Brunoni AR, Boggio PS, De Raedt R, Bensenor IM, Lotufo PA, Namur V, et al. Cognitive control therapy and transcranial direct current stimulation for depression: a randomized, double-blinded, controlled trial. J Affect Disord 2014;162:43–9. - PubMed
    1. Alizadehgoradel J, Nejati V, Movahed FS, Imani S, Taherifard M, Mosayebi-Samani M, et al. Repeated stimulation of the dorsolateral-prefrontal cortex improves executive dysfunctions and craving in drug addiction: a randomized, double-blind, parallel-group study. Brain Stimulation 2;13(3):582–93. 10.1016/j.brs.2019.12.028. - DOI - PubMed
    1. Nissim NR, O'Shea A, Indahlastari A, Telles R, Richards L, Porges E, et al. Effects of in-scanner bilateral frontal tDCS on functional connectivity of the working memory network in older adults. Front Aging Neurosci 2019;11:51. - PMC - PubMed
    1. Badran B, Caulfield K, Lopez J, Cox C, Stomberg-Firestein S, Devries W, et al. Personalized TMS helmets for quick and reliable TMS administration outside of a laboratory setting. Brain Stimulation 2020;13. - PMC - PubMed

Publication types