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. 2020 Jul;20(7):389-391.
doi: 10.1038/s41577-020-0343-0.

COVID-19: the vasculature unleashed

Laure-Anne Teuwen  1   2   3 , Vincent Geldhof  1 , Alessandra Pasut  1 , Peter Carmeliet  4   5
Affiliations

COVID-19: the vasculature unleashed

Laure-Anne Teuwen et al. Nat Rev Immunol. 2020 Jul.

Erratum in

Abstract

On the basis of emerging evidence from patients with COVID-19, we postulate that endothelial cells are essential contributors to the initiation and propagation of severe COVID-19. Here, we discuss current insights into the link between endothelial cells, viral infection and inflammatory changes and propose novel therapeutic strategies.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Proposed vessel–lung tissue interface in normal state and in COVID-19 disease.
a | On the left, the normal interface between the alveolar space and endothelial cells is depicted; the right side highlights pathophysiological features of coronavirus disease 2019 (COVID-19) in the lung, including loss of vascular integrity (1), activation of the coagulation pathway (2) and inflammation (3). b–d | Proposed contributing endothelial cell-specific mechanisms are detailed. ROS, reactive oxygen species; S1PR1, sphingosine 1 phosphate receptor 1; VWF, von Willebrand factor.
See this image and copyright information in PMC

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