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. 2020 Feb;31(3):230-236.
doi: 10.1055/s-0037-1611848. Epub 2019 Jun 6.

Synthetic utility of one-pot chemoenzymatic reaction sequences

Tyler J Doyon  1   2 , Alison R H Narayan  1   2   3
Affiliations

Synthetic utility of one-pot chemoenzymatic reaction sequences

Tyler J Doyon et al. Synlett. 2020 Feb.

Abstract

In recent years, there has been a rapid and sustained increase in the development and use of one-pot chemoenzymatic reaction processes for the efficient synthesis of high-value molecules. This strategy can provide a number of advantages over traditional synthetic methods, including high levels of selectivity in reactions, mild and sustainable reaction conditions, and the ability to rapidly build molecular complexity in a single reaction vessel. Here, we present several examples of chemoenzymatic one-pot reaction sequences that demonstrate the diversity of transformations that can be incorporated in these processes.

Keywords: biocatalysis; chemoenzymatic; one-pot process.

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Figures

Scheme 1.
Scheme 1.
(A) Chemical functionalization of an enzymatic product. (B) Chemical generation of substrate for an enzymatic reaction. S: substrate, P: product, R: chemical modification.
Scheme 2.
Scheme 2.
Stereodivergent chemoenzymatic one-pot synthesis of 1,3-diols.–
Scheme 3.
Scheme 3.
Chemoenzymatic one-pot syntheses of cyclic amines.–
Scheme 4.
Scheme 4.
Chemoenzymatic synthesis of enantioenriched benzylic alcohols.
Scheme 5.
Scheme 5.
Chemoenzymatic reactions involving transition metal catalysis.–
Scheme 6.
Scheme 6.
Biocatalyst-initiated ortho-quinone methide generation and diversification. *Yield from reactions with purified benzyl alcohol (46)
Scheme 7.
Scheme 7.
Chemoenzymatic syntheses of diverse sorbicillinoids.–
See this image and copyright information in PMC

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