Erratum: Ion Therapy: A Novel Strategy for Acute Myocardial Infarction

Abstract

[This corrects the article DOI: 10.1002/advs.201801260.].

Figure 1

Effects of silicon‐enriched ion extracts on NRCMs cell viability under normal and glucose/oxygen deprived conditions. a) NRCM cell viability cultured in different CS extracts diluted with DMEM for 1, 3, and 5 d under normoxia conditions (*p < 0.01 vs control group for Day 1; †p < 0.01 vs control group for Day 3; ‡ p < 0.01 vs control group for Day 5; n = 6 for each group).

Figure 6

Effect of “ion therapy” on cardiac function and heart remodeling as well as hypertrophy post‐MI in vivo. b) Cardiac function measured by left ventricular end‐diastolic diameter (LVEDD), LV end‐systolic diameter (LVESD), the percentage of LV ejection fraction (EF) and fractional shortening (FS) values and changes before and post “ion therapy”. *p < 0.05 versus AMI group, †p < 0.01 versus AMI group.

Figure S7

Effect of “ion therapy” of different concentrations on heart remodeling as well as hypertrophy post AMI in vivo. a) Representative Masson's trichrome staining of heart sections evaluating collagen deposition 4 weeks after surgery. c) Quantitative analysis of the area of fibrosis. Sham group was set as 0% and #P < 0.001 vs. AMI group (5 pictures for each group). b) Representative pictures of heart samples indicating hypertrophy degrees. *P < 0.05 vs. AMI group, **P < 0.01 vs. AMI group. Sham group n = 3; AMI group n = 3; AMI+1/2CS1 group n = 3 and AMI+ CS group n = 3; mean ± SD.

Figure 4

Effect of silicon‐enriched ion extract on the expression of gap junction associated Cx43 in NRCMs under glucose/oxygen deprived conditions in vitro. a) Representative images of Cx43 immunofluorescence staining of NRCMs cultured in silicon‐enriched ion extracts under glucose/oxygen deprived conditions for 90 and 120 min, respectively. Scale bars represent 25 µm.

Figure 10

Bio‐distribution and metabolism of Si and acute toxicity of “ion therapy.” g) Serum expression of ALT, AST, and Cr level in each groups after injection for 7 d. h) Serum expression of ALT, AST, and Cr level in each groups after injection for 14 d. Sham group n = 4; AMI group n = 7 and AMI+CS group n = 13. *p < 0.05 versus sham group or day 0, **p < 0.01 versus Day 0, †p < 0.05 versus AMI group; mean ± SD.