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Case Reports
. 2020 Mar 2;7(2):e00336.
doi: 10.14309/crj.0000000000000336. eCollection 2020 Feb.

Vanishing Bile Duct Syndrome Preceding the Diagnosis of Hodgkin Lymphoma

Chimaobi Anugwom  1 , Grete Goetz  1 , Mohamed Hassan  1
Affiliations
Case Reports

Vanishing Bile Duct Syndrome Preceding the Diagnosis of Hodgkin Lymphoma

Chimaobi Anugwom et al. ACG Case Rep J. .

Abstract

Vanishing bile duct syndrome is an acquired liver disease characterized by the progressive destruction and loss of intrahepatic bile ducts. It usually signifies end-stage cholestatic liver disease and is characterized by ductopenia on liver biopsy specimen. We present a case of vanishing bile duct syndrome as the presenting symptom in a patient with Hodgkin lymphoma with subsequent improvement after adequate treatment of the lymphoma.

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Figures

Figure 1.
Figure 1.
Liver biopsy showing the absence of native bile duct using hematoxylin and eosin stain (A) and cytokeratin 7 (B and C).
Figure 2.
Figure 2.
Trend of liver enzymes with chemotherapy for Hodgkin lymphoma. ALP, alkaline phosphatase; ALT, alanine transaminase; AST, aspartate transaminase.
See this image and copyright information in PMC

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