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. 2019 Jul 23:3:2470547019861417.
doi: 10.1177/2470547019861417. eCollection 2019 Jan-Dec.

Neurophysiological Effect of Ketamine on Prefrontal Cortex in Treatment-Resistant Depression: A Combined Transcranial Magnetic Stimulation-Electroencephalography Study

Nithya Ramakrishnan  1 , Nicholas R E Murphy  1 , Christopher P Walker  2 , Valeria A Cuellar Leal  2 , Jair C Soares  2 , Raymond Y J Cho  1   3 , Sudhakar Selvaraj  2
Affiliations

Neurophysiological Effect of Ketamine on Prefrontal Cortex in Treatment-Resistant Depression: A Combined Transcranial Magnetic Stimulation-Electroencephalography Study

Nithya Ramakrishnan et al. Chronic Stress (Thousand Oaks). .
No abstract available

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Modulation of TEPs and Local Field Power by single pulse TMS administered to DLPFC. (a) The mean SOUND corrected Local Field Power at DLPFC ROI. LMFA-AUC was calculated by summation of LMFA amplitude from 55 to 275ms after TMS pulse. (b) The mean SOUND corrected N100 peak-to-peak amplitude computed between 55 ms and 275ms after TMS pulse. (c) Butterfly plot of TEPs for all electrodes (green) and electrode F3 (red) with most pronounced TEP components labeled. (d) Schematic of the DLPFC ROI shaded in red.
Figure 2.
Figure 2.
a-b: Relationship of cortical excitability measures (LMFA-AUC) and depression scores (a) MADRS and (b)HAM-D. c-d: Pairwise comparison of the session with significance values adjusted by Bonferroni correction for multiple tests for all patients.
See this image and copyright information in PMC

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