lncRNA-NRF is a Potential Biomarker of Heart Failure After Acute Myocardial Infarction

Abstract

Long non-coding RNAs (lncRNAs) are a new focus in cardiovascular diseases. The necrosis-related factor (NRF) is a newly discovered lncRNA, which is increased in myocardial injury. We investigated the role of lncRNA-NRF in heart failure (HF) after acute myocardial infarction (AMI) to find a biomarker for early HF detection. This was a cross-sectional study of 76 AMI patients with HF and 58 AMI patients without HF. lncRNA-NRF was shown to be increased in AMI patients with HF compared with AMI patients without HF and had predictive value for diagnosis of HF. It had a high diagnostic value for HF (AUC, 0.975), while the AUC for N-terminal pro-brain natriuretic peptide was 0.720. Our findings suggest that lncRNA-NRF may represent a marker of risk for development of HF post-AMI.

Keywords: Acute myocardial infarction; Diagnosis; Heart failure; lncRNA-NRF.

Fig. 1

Relative average lncRNA-NRF expression in all the patients. a Circulating lncRNA-NRF levels in AMI patients with HF and non-HF. b Venous blood NT-proBNP level in AMI patients with HF and non-HF. c Circulating lncRNA-NRF levels in heart failure and stable CAD patients and at the time of diagnosis in patients with HF after AMI and non-HF after AMI. *P < 0.05, **P < 0.01, ***P < 0.001

Fig. 2

Relationship between lncRNA-NRF levels and coronary disease burden at intraprocedural timepoint. a LncRNA-NRF expression levels in AMI patients with different coronary lesions. b LncRNA-NRF expression levels in AMI patients with different TIMI flow

Fig. 3

ROC curve for patients with HF after AMI based on the expression of lncRNA-NRF and NT-proBNP at the time of diagnosis