Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun;26(6):1287-1290.
doi: 10.3201/eid2606.191431.

Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France

Christophe Rodriguez, Guillaume Gricourt, Melissa Ndebi, Vanessa Demontant, Lila Poiteau, Sonia Burrel, David Boutolleau, Paul-Louis Woerther, Vincent Calvez, Sebastian Stroer, Jean-Michel Pawlotsky

Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France

Christophe Rodriguez et al. Emerg Infect Dis. 2020 Jun.

Abstract

We report the discovery of a new orthobunyavirus, Cristoli virus, by means of shotgun metagenomics. The virus was identified in an immunodepressed patient with fatal encephalitis. Full-length genome sequencing revealed high-level expression of a virulence factor, possibly explaining the severity of the infection. The patient's recent history suggests circulation in France.

Keywords: Cristoli virus; France; meningitis/encephalitis; orthobunyavirus; shotgun metagenomics; viruses.

PubMed Disclaimer

Figures

Figure
Figure
Cerebral magnetic resonance imaging scans compatible with the diagnosis of encephalitis in a 58-year-old woman, France. Fluid-attenuated inversion recovery (FLAIR) and T2 hypersignals in limbic system structures, including both amygdalae (A, arrows), temporal poles (B, arrows), and insular cortex (C), associated with FLAIR hyperintensities of the cerebellar cortex (D).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Elliott RM. Orthobunyaviruses: recent genetic and structural insights. Nat Rev Microbiol. 2014;12:673–85. 10.1038/nrmicro3332 - DOI - PubMed
    1. Li D. A highly pathogenic new bunyavirus emerged in China. Emerg Microbes Infect. 2013;2:e1. 10.1038/emi.2013.1 - DOI - PMC - PubMed
    1. Huang YS, Higgs S, Vanlandingham DL. Emergence and re-emergence of mosquito-borne arboviruses. Curr Opin Virol. 2019;34:104–9. 10.1016/j.coviro.2019.01.001 - DOI - PubMed
    1. Huang B, Allcock R, Warrilow D. Newly characterized arboviruses of northern Australia. Virol Rep. 2016;6:11–7. 10.1016/j.virep.2016.01.001 - DOI
    1. Granerod J, Ambrose HE, Davies NW, Clewley JP, Walsh AL, Morgan D, et al.; UK Health Protection Agency (HPA) Aetiology of Encephalitis Study Group. Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis. 2010;10:835–44. 10.1016/S1473-3099(10)70222-X - DOI - PubMed