Which cancer type has the highest risk of COVID-19 infection?

Changjing Cai¹, Omar Abdihamid Ahmed², Hong Shen³, Shan Zeng⁴

Affiliations

¹ Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008; Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008.
² Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008.
³ Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008; Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China, 410008.
⁴ Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008; Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China, 410008. Electronic address: zengshan2000@csu.edu.cn.

PMID: 32442454
PMCID: PMC7235576
DOI: 10.1016/j.jinf.2020.05.028

Comment

Which cancer type has the highest risk of COVID-19 infection?

Changjing Cai et al. J Infect. 2020 Oct.

. 2020 Oct;81(4):647-679.

doi: 10.1016/j.jinf.2020.05.028. Epub 2020 May 19.

Authors

Changjing Cai¹, Omar Abdihamid Ahmed², Hong Shen³, Shan Zeng⁴

Affiliations

¹ Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008; Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008.
² Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008.
³ Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008; Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China, 410008.
⁴ Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008; Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China, 410008. Electronic address: zengshan2000@csu.edu.cn.

PMID: 32442454
PMCID: PMC7235576
DOI: 10.1016/j.jinf.2020.05.028

No abstract available

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Figures

Fig 1 — **Fig. 1**
Which cancer type has the highest risk of COVID-19 infection? (A) The expression level of ACE2 in pan-cancer analysis. (B) The expression level of TMPRSS2 in pan-cancer. (C) The body map of the risk of COVID-19 infection in cancer. (Esophageal carcinoma (ESCA), Kidney renal papillary cell carcinoma (KIRP), Lung adenocarcinoma (LUAD), Uterine Corpus Endometrial Carcinoma (UCEC), Kidney Chromophobe (KICH), Prostate adenocarcinoma (PRAD). P-value: 0 ≤ ******* < 0.001 ≤ ** < 0.01 ≤ * < 0.05 ≤ . < 0.1)

See this image and copyright information in PMC

Comment in

The high expression of SARS-CoV-2 cell receptors might lead to higher COVID-19 infection rates in cancer patients.
Qiu S, Zhang Y, Wang D, Hu Y. Qiu S, et al. J Infect. 2021 Dec;83(6):709-737. doi: 10.1016/j.jinf.2021.08.045. Epub 2021 Sep 2. J Infect. 2021. PMID: 34481830 Free PMC article. No abstract available.
Genetic variation associated with COVID-19 is also associated with endometrial cancer.
Gao R, Xu Y, Zhu G, Zhou S, Li H, Han G, Su W, Wang R. Gao R, et al. J Infect. 2022 May;84(5):e85-e86. doi: 10.1016/j.jinf.2022.01.026. Epub 2022 Jan 22. J Infect. 2022. PMID: 35077768 Free PMC article. No abstract available.

Comment on

Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis.
Zheng Z, Peng F, Xu B, Zhao J, Liu H, Peng J, Li Q, Jiang C, Zhou Y, Liu S, Ye C, Zhang P, Xing Y, Guo H, Tang W. Zheng Z, et al. J Infect. 2020 Aug;81(2):e16-e25. doi: 10.1016/j.jinf.2020.04.021. Epub 2020 Apr 23. J Infect. 2020. PMID: 32335169 Free PMC article.

References

1. Zheng Z, Peng F, Xu B. Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis. J Infect. 2020 - PMC - PubMed
1. Mehta V, Goel S, Kabarriti R. Case Fatality Rate of Cancer Patients with COVID-19 in a New York Hospital System. Cancer discovery. 2020 - PMC - PubMed
1. Ziegler CGK, Allon SJ, Nyquist SK. SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell. 2020 - PMC - PubMed
1. Li T, Fan J, Wang B. TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells. Cancer Res. 2017;77(21):e108–ee10. - PMC - PubMed
1. Richardson S, Hirsch JS, Narasimhan M. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. 2020 - PMC - PubMed

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Which cancer type has the highest risk of COVID-19 infection?

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Which cancer type has the highest risk of COVID-19 infection?

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