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. 2020 Jun;120(6):38-46.
doi: 10.1097/01.NAJ.0000668736.80609.4e.

CE: Opioid Use Disorder: Pathophysiology, Assessment, and Effective Interventions

Kate Garland Brown  1 , Bernadette Capili
Affiliations

CE: Opioid Use Disorder: Pathophysiology, Assessment, and Effective Interventions

Kate Garland Brown et al. Am J Nurs. 2020 Jun.

Abstract

Opioid use disorder (OUD) is a chronic, relapsing disease. Genetic variability, dysregulated stress system response, and history of opioid experimentation or escalating exposure all contribute to the likelihood of developing OUD, which produces complex brain changes that make it difficult to stop opioid use. Understanding the neurobiology of OUD helps nurses anticipate the behaviors of patients with OUD and approach them with empathy. Here, the authors discuss the pathophysiology of OUD, available screening tools, medical treatments, and behavioral interventions that have demonstrated efficacy in reducing substance use.

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Figures

Figure 1.
Figure 1.
Effect of Opioids on the Brain
Figure 2.
Figure 2.
Effects of Opioids on the Stress Response
See this image and copyright information in PMC

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