Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment
- PMID: 32443469
- PMCID: PMC7281116
- DOI: 10.3390/pathogens9050385
Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment
Abstract
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB) and it represents a persistent public health threat for a number of complex biological and sociological reasons. According to the most recent Global Tuberculosis Report (2019) edited by the World Health Organization (WHO), TB is considered the ninth cause of death worldwide and the leading cause of mortality by a single infectious agent, with the highest rate of infections and death toll rate mostly concentrated in developing and low-income countries. We present here the editorial section to the Special Issue entitled "Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment" that includes 7 research articles and a review. The scientific contributions included in the Special Issue mainly focus on the characterization of MTB strains emerging in TB endemic countries as well as on multiple mechanisms adopted by the bacteria to resist and to adapt to antitubercular therapies.
Keywords: M. tuberculosis; antitubercular drug discovery; antitubercular treatments; host-pathogen interactions; immune response; tuberculosis.
Conflict of interest statement
The authors declare no conflict of interest.
References
-
- World Health Organization . Global tuberculosis Report WHO 2018. Volume 69 WHO; Geneva, Switzerland: 2018.
-
- Political Declaration of the High-Level Meeting of the General Assembly on the Fight against Tuberculosis. [(accessed on 16 May 2020)];2018 Available online: https://digitallibrary.un.org/record/1649568.
-
- Treatment Action Group . Tuberculosis Research Funding Trends 2005–2017. Treatment Action Group; New York, NY, USA: 2018. [(accessed on 16 May 2020)]. Available online: https://www.treatmentactiongroup.org/wp-content/uploads/2018/11/tb_fundi....
-
- Mupfumi L., Mpande C.A., Reid T., Moyo S., Shin S.S., Zetola N., Mogashoa T., Musonda R.M., Kasvosve I., Scriba T.J., et al. Immune Phenotype and Functionality of Mtb-Specific T-Cells in HIV/TB Co-infected patients on antiretroviral treatment. Pathogens. 2020;9:180. doi: 10.3390/pathogens9030180. - DOI - PMC - PubMed
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