Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Dec;8(12):5504-12.
doi: 10.1128/mcb.8.12.5504-5512.1988.

Silk gland-specific tRNA(Ala) genes are tightly clustered in the silkworm genome

D C Underwood  1 , H Knickerbocker, G Gardner, D P Condliffe, K U Sprague
Affiliations

Silk gland-specific tRNA(Ala) genes are tightly clustered in the silkworm genome

D C Underwood et al. Mol Cell Biol. 1988 Dec.

Abstract

To understand the basis for tissue-specific production and accumulation of alanine tRNA in silkworms, we have examined the organization of the genes that code for silk gland-specific and constitutive alanine tRNAs. We have found that all of the silk gland-specific tRNA(Ala) genes (approximately 20) appear to be tightly clustered at a single locus in the Bombyx genome. These genes are arranged in tandem at intervals of approximately 150 base pairs. In contrast to the arrangement of the silk gland-specific tRNA(Ala) genes, most of the 20 to 30 constitutive tRNA(Ala) genes are dispersed in the genome. Silk gland-specific tRNA(Ala) genes are not amplified or grossly rearranged in the silk gland. Thus it is likely that differential transcription, rather than changes in gene number or structure, accounts for the tissue-specific accumulation of tRNA(Ala).

PubMed Disclaimer

References

    1. J Mol Biol. 1974 Jul 15;86(4):843-53 - PubMed
    1. Biochem Biophys Res Commun. 1966 Jun 13;23(5):641-6 - PubMed
    1. J Mol Biol. 1974 Jun 15;86(1):97-108 - PubMed
    1. Adv Protein Chem. 1958;13:107-242 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Jun;80(11):3416-20 - PubMed

Publication types

Substances

Associated data