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Review
. 2020 Oct;8(10):946-949.
doi: 10.1016/S2213-2600(20)30217-4. Epub 2020 Apr 28.

Immunotherapies for COVID-19: lessons learned from sepsis

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Review

Immunotherapies for COVID-19: lessons learned from sepsis

Kenneth E Remy et al. Lancet Respir Med. 2020 Oct.
No abstract available

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Figures

Figure
Figure
Immunological landscape in polymicrobial sepsis (A) and COVID-19 (B) Bullet points refer to the symptoms seen throughout disease progression. MOF=multiorgan failure. COVID-19=coronavirus disease 19. MDSC=myeloid-derived suppressor cells. HLA-DR=human leukocyte antigen-DR. sPD-L1=soluble programmed cell death protein 1.

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References

    1. Kotch C, Barrett D, Teachey DT. Tocilizumab for the treatment of chimeric antigen receptor T cell-induced cytokine release syndrome. Expert Rev Clin Immunol. 2019;15:813–822. - PMC - PubMed
    1. Le RQ, Li L, Yuan W, et al. FDA Approval Summary: Tocilizumab for treatment of chimeric antigen receptor T cell-induced severe or life-threatening cytokine release syndrome. Oncologist. 2018;23:943–947. - PMC - PubMed
    1. Chousterman BG, Swirski FK, Weber GF. Cytokine storm and sepsis disease pathogenesis. Semin Immunopathol. 2017;39:517–528. - PubMed
    1. Giamarellos-Bourboulis EJ. Failure of treatments based on the cytokine storm theory of sepsis: time for a novel approach. Immunotherapy. 2013;5:207–209. - PubMed
    1. Luo P, Liu Y, Qiu L, Liu X, Liu D, Li J. Tocilizumab treatment in COVID-19: a single center experience. J Med Virol. 2020 doi: 10.1002/jmv.25801. published online April 6. - DOI - PMC - PubMed

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