Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Jul 16;56(1):2001589.
doi: 10.1183/13993003.01589-2020. Print 2020 Jul.

COVID-19 and the nicotinic cholinergic system

Affiliations
Comment

COVID-19 and the nicotinic cholinergic system

Konstantinos Farsalinos et al. Eur Respir J. .

Abstract

The prevalence of smoking among hospitalised COVID-19 patients is low. COVID-19 manifestations could be linked to impairment of the cholinergic anti-inflammatory pathway. Nicotinic cholinergic agonists should be examined as potential therapeutic options. https://bit.ly/2zfUZ1S

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: K. Farsalinos has nothing to disclose. Conflict of interest: A. Angelopoulou has nothing to disclose. Conflict of interest: N. Alexandris has nothing to disclose. Conflict of interest: K. Poulas has nothing to disclose.

Comment in

Comment on

References

    1. Leung JM, Yang CX, Tam A, et al. . ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19. Eur Respir J 2020; 55: 200688. doi:10.1183/13993003.00688-2020 - DOI - PMC - PubMed
    1. Russo P, Bonassi S, Giacconi R, et al. . COVID-19 and smoking: is nicotine the hidden link? Eur Respir J 2020; 55: 2001116. doi:10.1183/13993003.01116-2020 - DOI - PMC - PubMed
    1. Leung JM, Yang CX, Sin DD. COVID-19 and nicotine as a mediator of ACE-2. Eur Respir J 2020; 55: 2001261. doi:10.1183/13993003.01261-2020 - DOI - PMC - PubMed
    1. Farsalinos K, Barbouni A, Niaura R. Systematic review of the prevalence of current smoking among hospitalized COVID-19 patients in China: could nicotine be a therapeutic option? Intern Emerg Med 2020; in press [https://doi.org/10.1007/s11739-020-02355-7]. doi:10.1007/s11739-020-02355-7 - DOI - PMC - PubMed
    1. Centers for Disease Control and Prevention. Preliminary estimates of the prevalence of selected underlying health conditions among patients with coronavirus disease 2019 — United States, February 12–March 28, 2020. MMWR Morb Mortal Wkly Rep 2020; 69: 382–386. doi:10.15585/mmwr.mm6913e2 - DOI - PMC - PubMed