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Observational Study
. 2020 Oct 1;56(4):2000006.
doi: 10.1183/13993003.00006-2020. Print 2020 Oct.

An observational study of the lung clearance index throughout childhood in cystic fibrosis: early years matter

Gwyneth Davies  1   2   3 , Sanja Stanojevic  4   3 , Emma Raywood  5 , Julie A Duncan  5 , Janet Stocks  5 , Sooky Lum  5 , Andrew Bush  6 , Laura Viviani  5 , Angie Wade  7 , Alistair Calder  8 , Catherine M Owens  8 , Christophe Goubau  5 , Siobhán B Carr  6 , Cara J Bossley  9 , Caroline Pao  10 , Paul Aurora  5   2 ; London Cystic Fibrosis Collaboration
Affiliations
Observational Study

An observational study of the lung clearance index throughout childhood in cystic fibrosis: early years matter

Gwyneth Davies et al. Eur Respir J. .

Abstract

Lung clearance index (LCI) in the early years was associated with LCI during adolescence in children with cystic fibrosis. Pre-school LCI may help to identify children in whom treatment could be intensified. https://bit.ly/2yKyMbM

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Conflict of interest statement

Conflict of interest: G. Davies reports personal fees for lectures from Chiesi, outside the submitted work. Conflict of interest: S. Stanojevic has nothing to disclose. Conflict of interest: E. Raywood has nothing to disclose. Conflict of interest: J.A. Duncan has nothing to disclose. Conflict of interest: J. Stocks has nothing to disclose. Conflict of interest: S. Lum has nothing to disclose. Conflict of interest: A. Bush has nothing to disclose. Conflict of interest: L. Viviani has nothing to disclose. Conflict of interest: A. Wade has nothing to disclose. Conflict of interest: A. Calder has nothing to disclose. Conflict of interest: C.M. Owens has nothing to disclose. Conflict of interest: C. Goubau has nothing to disclose. Conflict of interest: S.B. Carr reports non-financial support and advisory board work from Chiesi Pharmaceuticals, lecture fees from Teva, travel support, lecture fees, advisory board and steering committee work from Vertex, advisory board work from Zambon, consultancy fees from Insmed, outside the submitted work. Conflict of interest: C.J. Bossley has nothing to disclose. Conflict of interest: C. Pao has nothing to disclose. Conflict of interest: P. Aurora reports grants from CF Trust (UK), during the conduct of the study; personal fees from Vertex Pharmaceuticals, outside the submitted work.

Figures

FIGURE 1
FIGURE 1
Change in lung clearance index (LCI) with age in healthy subjects (HC) and those with cystic fibrosis (CF) throughout childhood. a) Rate of change in LCI with age in health (slope 0.04 (95% CI 0.002; 0.08) and CF (slope 0.18 (95% CI 0.14; 0.21). The rate of change in CF was significantly different from the healthy group (interaction coefficient −0.05 (95% CI −0.09; −0.002). Results represent mean LCI with 95% confidence intervals for the CF group (dashed line, pale shaded area) and contemporaneous controls (solid line, darker shaded area), respectively. b) Individual changes in LCI in health (solid line) and CF (dashed line).
See this image and copyright information in PMC

References

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