Management of Lupus Nephritis in Children

Abstract

Lupus nephritis affects 50-75% of all children with systemic lupus erythematosus with a higher prevalence in Asians. It remains a major contributor to morbidity and mortality in childhood onset lupus. Proliferative lupus nephritis (class III and class IV) warrants aggressive treatment to prevent progression to end stage renal disease. Newer immunosuppressive agents available in the last decade offer more options to treat lupus nephritis. Despite guidelines from professional bodies, there remains a lack of consensus on the treatment of refractory disease and duration of maintenance therapy. We review the treatment options for pediatric patients with lupus nephritis based on studies and published guidelines in the last decade, and highlight opportunities for continued improvement in care.