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Randomized Controlled Trial
. 2020 Dec 15;71(12):3222-3225.
doi: 10.1093/cid/ciaa609.

Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants' Nasopharynx: A Randomized Controlled Trial

Abdoulie Bojang  1 , Sarah L Baines  2 , Bully Camara  1 , Romain Guerillot  2 , Liam Donovan  2 , Raquel Sánchez Marqués  1 , Ousman Secka  1 , Umberto D'Alessandro  1 , Christian Bottomley  3 , Benjamin P Howden  2   4 , Anna Roca  1
Affiliations
Randomized Controlled Trial

Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants' Nasopharynx: A Randomized Controlled Trial

Abdoulie Bojang et al. Clin Infect Dis. .

Abstract

In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers had been treated with the drug had higher prevalence of macrolide-resistance genes msr(A) and ermC at 28 days but not at 12 months. The 2 genes were positively associated in the nasopharynx.

Clinical trials registration: NCT1800942.

Trial registration: ClinicalTrials.gov NCT01800942.

Keywords: ermC; msr(A); azithromycin; NPS; The Gambia.

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References

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