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Comment
. 2020 Aug;598(15):3065-3066.
doi: 10.1113/JP280096. Epub 2020 Jun 10.

Linking lymphatic function to disease

Walter L Murfee  1 , Jerome W Breslin  2
Affiliations
Comment

Linking lymphatic function to disease

Walter L Murfee et al. J Physiol. 2020 Aug.
No abstract available

Keywords: contraction; ion channel; lymphatic pumping; lymphatic vessel; smooth muscle cell.

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Conflict of interest statement

CONFLICTS OF INTEREST

The author does not have any conflicts of interests on the submission.

Figures

Figure 1:
Figure 1:
Development of lymphatic smooth muscle cell (SMC specific mechanisms represent therapeutic targets for clinical translation. Interstitial fluid enters initial lymphatics and drains through collecting vessels, which are wrapped by SMCs. SMC constriction regulated by ion fluxes, receptor-mediated signaling, and interrelationships with other cell types is critical for lymphatic pumping and function. As highlighted by the work by Davis et al. in the current Journal of Physiology issue, basic science discovery of SMC mechanisms motivate new opportunities for translating an advanced understanding to treatment Cantú Syndrome and other diseases associated with lymphedema.
See this image and copyright information in PMC

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References

    1. Breslin JW, Yang Y, Scallan JP, Sweat RS, Adderley SP, Murfee WL. (2018). Lymphatic Vessel Network Structure and Physiology. Compr Physiol 13;9(1):207–299. - PMC - PubMed
    1. Davis M, Kim H, Zawieja S, Castorena-Gonzalez J, Gui P, Li M, Saunders B, Zinselmeyer B, Randolph G, Remedi M, Nichols C. (2020). Kir6.1-Dependent KATP Channels in Lymphatic Smooth Muscle and Vessel Dysfunction in Mice with Kir6.1 Gain-of-Function. Journal of Physiology. (JP-RP-2020–279612R1) - PMC - PubMed

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