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Review
. 2020 May:45:101831.
doi: 10.1016/j.scr.2020.101831. Epub 2020 Apr 27.

Human pluripotent stem cell-derived cardiac stromal cells and their applications in regenerative medicine

Martha E Floy  1 , Taylor D Mateyka  1 , Koji L Foreman  1 , Sean P Palecek  2
Affiliations
Review

Human pluripotent stem cell-derived cardiac stromal cells and their applications in regenerative medicine

Martha E Floy et al. Stem Cell Res. 2020 May.

Abstract

Coronary heart disease is one of the leading causes of death in the United States. Recent advances in stem cell biology have led to the development and engineering of human pluripotent stem cell (hPSC)-derived cardiac cells and tissues for application in cellular therapy and cardiotoxicity studies. Initial studies in this area have largely focused on improving differentiation efficiency and maturation states of cardiomyocytes. However, other cell types in the heart, including endothelial and stromal cells, play crucial roles in cardiac development, injury response, and cardiomyocyte function. This review discusses recent advances in differentiation of hPSCs to cardiac stromal cells, identification and classification of cardiac stromal cell types, and application of hPSC-derived cardiac stromal cells and tissues containing these cells in regenerative and drug development applications.

Keywords: Cardiac; Cardiomyocytes; Human pluripotent stem cells; Stromal cells.

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Figures

Figure 1:
Figure 1:
Schematic of cardiac stromal cell composition and localization in cardiac wall.
Figure 2:
Figure 2:
Diagram strategies to induce cardiac stromal cell differentiation from hPSCs where blue text indicates factors and black text indicates cell types.
Figure 3:
Figure 3:
Applications of cardiac stromal cells.
See this image and copyright information in PMC

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