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Review
. 2020 Nov:107:36-45.
doi: 10.1016/j.semcdb.2020.04.016. Epub 2020 May 20.

Roles of CDK/Cyclin complexes in transcription and pre-mRNA splicing: Cyclins L and CDK11 at the cross-roads of cell cycle and regulation of gene expression

Pascal Loyer  1 , Janeen H Trembley  2
Affiliations
Free article
Review

Roles of CDK/Cyclin complexes in transcription and pre-mRNA splicing: Cyclins L and CDK11 at the cross-roads of cell cycle and regulation of gene expression

Pascal Loyer et al. Semin Cell Dev Biol. 2020 Nov.
Free article

Abstract

Cyclin Dependent Kinases (CDKs) represent a large family of serine/threonine protein kinases that become active upon binding to a Cyclin regulatory partner. CDK/cyclin complexes recently identified, as well as "canonical" CDK/Cyclin complexes regulating cell cycle, are implicated in the regulation of gene expression via the phosphorylation of key components of the transcription and pre-mRNA processing machineries. In this review, we summarize the role of CDK/cyclin-dependent phosphorylation in the regulation of transcription and RNA splicing and highlight recent findings that indicate the involvement of CDK11/cyclin L complexes at the cross-roads of cell cycle, transcription and RNA splicing. Finally, we discuss the potential of CDK11 and Cyclins L as therapeutic targets in cancer.

Keywords: CCNL1; CCNL2; CDK11; Cell Cycle; Cyclin L; Transcription; cancer; pre-mRNA splicing.

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