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Comment
. 2020 Sep;45(9):721-723.
doi: 10.1016/j.tibs.2020.05.004. Epub 2020 May 21.

Managing Hyperosmotic Stress through Phase Separation

Ivan Peran  1 , Nafiseh Sabri  1 , Tanja Mittag  2
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Managing Hyperosmotic Stress through Phase Separation

Ivan Peran et al. Trends Biochem Sci. 2020 Sep.

Abstract

In a recent study, Yasuda et al. show how liquid-liquid phase separation (LLPS) under hyperosmotic stress conditions allows cells to react to ubiquitinated proteins and to assemble nuclear, liquid compartments that recruit proteasomes and result in aggregate clearance.

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