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Multicenter Study
. 2020 Aug:67:101731.
doi: 10.1016/j.canep.2020.101731. Epub 2020 May 19.

Maternal and paternal ages at conception of index child and risk of childhood acute leukaemia: A multicentre case-control study in Greater Mexico City

Elva Jiménez-Hernández  1 , David Aldebarán Duarte-Rodríguez  2 , Juan Carlos Núñez-Enriquez  3 , Janet Flores-Lujano  4 , Jorge Alfonso Martín-Trejo  5 , Laura Eugenia Espinoza-Hernández  6 , José Arellano-Galindo  7 , Aurora Medina-Sanson  8 , Xochiketzalli García-Jiménez  9 , Rogelio Paredes-Aguilera  10 , Luz Victoria Flores-Villegas  11 , José Gabriel Peñaloza-González  12 , José Refugio Torres-Nava  13 , Rosa Martha Espinosa-Elizondo  14 , Raquel Amador-Sánchez  15 , Juan José Dosta-Herrera  16 , Javier Anastacio Mondragón-García  17 , Heriberto Valdés-Guzmán  18 , Laura Mejía-Pérez  19 , Gilberto Espinoza-Anrubio  20 , María Minerva Paz-Bribiesca  21 , Perla Salcedo-Lozada  22 , Rodolfo Ángel Landa-García  23 , Rosario Ramírez-Colorado  24 , Luis Hernández-Mora  25 , María Luisa Pérez-Saldivar  26 , Marlene Santamaría-Ascencio  27 , Anselmo López-Loyola  28 , Arturo Hermilo Godoy-Esquivel  29 , Luis Ramiro García-López  30 , Alison Ireri Anguiano-Ávalos  31 , Karina Mora-Rico  32 , Alejandro Castañeda-Echevarría  33 , Roberto Rodríguez-Jiménez  34 , José Alberto Cibrian-Cruz  35 , Rocío Cárdenas-Cardos  36 , Martha Beatriz Altamirano-García  37 , Martin Sánchez-Ruiz  38 , Roberto Rivera-Luna  39 , Luis Rodolfo Rodríguez-Villalobos  40 , Francisco Hernández-Pérez  41 , Jaime Ángel Olvera-Durán  42 , Luis Rey García-Cortés  43 , Minerva Mata-Rocha  44 , Omar Alejandro Sepúlveda-Robles  45 , Vilma Carolina Bekker-Méndez  46 , Silvia Jiménez-Morales  47 , Haydee Rosas-Vargas  48 , Juan Manuel Mejía-Aranguré  49
Affiliations
Multicenter Study

Maternal and paternal ages at conception of index child and risk of childhood acute leukaemia: A multicentre case-control study in Greater Mexico City

Elva Jiménez-Hernández et al. Cancer Epidemiol. 2020 Aug.

Abstract

Background: The parental age at conception has been reported to be a risk factor for childhood acute leukaemia (AL); however, the relationship is controversial. The aim of the present study was to investigate the association between parental age at conception and the risk of AL in Mexican children, a population with a high incidence of the disease and a high prevalence of pregnancies in adolescents and young adults.

Methods: A multicentre case-control study was conducted. Incident AL cases younger than 17 years of age diagnosed between 2010 and 2015 were included. Controls were matched with cases according to age, sex, and health institution. Using logistic regression analysis, adjusted odds ratios (aOR) and 95 % confidence intervals (95 % CI) were calculated for each maternal stratum after adjusting for paternal age at conception of index child. The maternal age between 25 and 29.99 years was selected as the reference category.

Results: In most strata where maternal and paternal ages were assessed, no association was found with the risk of developing acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring. An increased risk for AML was observed when the mother was between 20 and 24.99 years of age and the father aged 25-29.99 years (aOR, 1.94; 95 % CI, 1.03-3.67). In addition, there was a positive association for ALL when the mother´s age was between 20 and 24.99 years and the father was <20 years of age, however, a very wide confidence interval was noted (aOR, 12.26; 95 % CI, 1.41-106.83).

Conclusion: In the present study, maternal and paternal ages assessed in different strata showed little association with risk of developing ALL and AML in children. Positive associations between risk of both types of childhood AL were observed with younger paternal and maternal ages.

Keywords: Children; Etiology; Leukemia; Parental age; Risk factors.

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