Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2021 Sep;268(9):3238-3248.
doi: 10.1007/s00415-020-09933-x. Epub 2020 May 23.

Association between Helicobacter Pylori infection and stroke: a meta-analysis of 273,135 patients

Mohamed Fahmy Doheim #  1 , Ahmad Amr Altaweel #  1 , Mohamed Gamal Elgendy #  1 , Alaa Ahmed Elshanbary  1 , Mahmoud Dibas  2 , Amira Abo Hegil Abo Ali  1 , Toqa Mahmoud Dahy  1 , Atef Khairy Sharaf  1 , Ameer E Hassan  3
Affiliations
Meta-Analysis

Association between Helicobacter Pylori infection and stroke: a meta-analysis of 273,135 patients

Mohamed Fahmy Doheim et al. J Neurol. 2021 Sep.

Abstract

Background: Stroke stands among the most leading causes of mortality worldwide. Although modifiable risk factors for stroke have been identified, current risk factors do not sufficiently explain the risk in young patients. Previous studies have postulated an association between infection by Helicobacter pylori (HP) and stroke.

Objective: To investigate the association between HP infection and stroke by using a systematic review and meta-analysis approach.

Methods: Four electronic search engines/libraries were systematically searched for relevant observational studies. Studies were screened for eligibility and data were extracted. The odds ratio (OR) and 95% confidence interval (95% CI) were combined under the random-effect model. The protocol was registered in PROSPERO (CRD42019123689).

Results: Among the included studies, 25 studies were analyzed for anti-HP IgG, 9 studies were for anti-Cag A, and 6 studies were for the C-urea breath test. The results showed that positive anti-HP IgG was significantly associated with an increased risk of stroke [OR (95% CI) = 1.43 (1.25-1.46)]. Similarly, both antiCag A and C-urea breath test were significantly associated with an increased risk of stroke with [OR (95% CI) = 1.77 (1.25-2.49)], and [OR (95% CI) = 2.21 (1.33-3.66)], respectively. Furthermore, our results indicated that positive anti-HP IgG was associated with stroke caused by atherothrombosis and small artery disease.

Conclusions: This study suggests that HP infection is significantly associated with increased risk of stroke. However, more well-designed studies are required to investigate if early HP eradication might decrease the incidence of stroke.

Keywords: Helicobacter pylori; Meta-analysis; Stroke; Systematic review.

PubMed Disclaimer

References

    1. Hankey GJ (2017) Stroke. Lancet 389(10069):641–654. https://doi.org/10.1016/s0140-6736(16)30962-x - DOI - PubMed
    1. Donnan GA, Fisher M, Macleod M, Davis SM (2008) Stroke. Lancet 371(9624):1612–1623. https://doi.org/10.1016/s0140-6736(08)60694-7 - DOI - PubMed
    1. Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, Perak AM, Rosamond WD, Roth GA, Sampson UKA, Satou GM, Schroeder EB, Shah SH, Shay CM, Spartano NL, Stokes A, Tirschwell DL, VanWagner LB, Tsao CW, American Heart Association Council on E, Prevention Statistics C, Stroke Statistics S (2020) Heart Disease and Stroke Statistics-2020 Update: a report from the American Heart Association. Circulation. https://doi.org/10.1161/CIR.0000000000000757 - DOI - PubMed - PMC
    1. WHO (2019) World health statistics 2019: monitoring health for the SDGs sustainable development goals. World Health Organization, Geneva
    1. Helfand M, Buckley DI, Freeman M, Fu R, Rogers K, Fleming C, Humphrey LL (2009) Emerging risk factors for coronary heart disease: a summary of systematic reviews conducted for the US Preventive Services Task Force. Ann Intern Med 151(7):496–507 - PubMed - DOI

LinkOut - more resources