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Review
. 2020 Dec;22(12):2170-2174.
doi: 10.1007/s12094-020-02372-0. Epub 2020 May 23.

Potential biomarkers for early detection of pancreatic ductal adenocarcinoma

D Kriz  1 , D Ansari  1 , R Andersson  2
Affiliations
Review

Potential biomarkers for early detection of pancreatic ductal adenocarcinoma

D Kriz et al. Clin Transl Oncol. 2020 Dec.

Abstract

Pancreatic cancer has the highest mortality amongst all major organ cancers. Early detection is key to reduce deaths related to pancreatic cancer. However, early detection has been challenged by the lack of non-invasive biomarkers with enough sensitivity and specificity to allow for screening. The gold standard is still carbohydrate antigen (CA 19-9), against which all new biomarkers must be evaluated. In this paper, we describe recent progress in the development of new pancreatic cancer biomarkers, focusing on proteins, metabolites, and genetic and epigenetic biomarkers. Although several promising biomarkers have been identified, they are all derived from retrospective studies and additional prospective studies are needed to confirm their clinical validity.

Keywords: Biomarkers; Early detection; Pancreatic cancer; Sensitivity; Specificity.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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