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. 2020 Jul;11(7):1605-1606.
doi: 10.1007/s13300-020-00844-8. Epub 2020 May 23.

Lack of Efficacy of SGLT2-i in Severe Pneumonia Related to Novel Coronavirus (nCoV) Infection: No Little Help from Our Friends

Affiliations

Lack of Efficacy of SGLT2-i in Severe Pneumonia Related to Novel Coronavirus (nCoV) Infection: No Little Help from Our Friends

Antonio Carlo Bossi et al. Diabetes Ther. 2020 Jul.
No abstract available

Keywords: COVID-19 related pneumonia; Non-diabetic patients; SGLT2-inhibitors.

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References

    1. Mudaliar S, Alloju S, Henry RR. Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis. Diabetes Care. 2016;39:1115–1122. doi: 10.2337/dc16-0542. - DOI - PubMed
    1. Inzucchi SE, Zinman B, Fitchett D, et al. How does empagliflozin reduce cardiovascular mortality? Insights from a mediation analysis of the EMPA-REG OUTCOME trial. Diabetes Care. 2018;41:356–363. doi: 10.2337/dc17-1096. - DOI - PubMed
    1. Verma S, McMurray JJ. SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review. Diabetologia. 2018;61:2108–2117. doi: 10.1007/s00125-018-4670. - DOI - PubMed
    1. Baartscheer A, Schumacher CA, Wust RC, et al. Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits. Diabetologia. 2017;60:568–573. doi: 10.1007/s00125-016-4134-x. - DOI - PMC - PubMed
    1. Bonnet F, Scheen AJ. Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: the potential contribution to diabetes complications and cardiovascular disease. Diabetes Metab. 2018;44:457–464. doi: 10.1016/j.diabet.2018.09.005. - DOI - PubMed

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