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. 2021 May;23(5):466-477.
doi: 10.1080/10286020.2020.1769609. Epub 2020 May 25.

Pharmacokinetic profile of diosgenin and trigonelline following intravenous and oral administration of fenugreek seed extract and pure compound in rabbit

Neda Mohamadi  1 , Fariba Sharififar  2 , Mehdi Ansari  3 , Mostafa Pournamdari  4 , Mahdieh Rezaei  5 , Navid Hassanabadi  5
Affiliations

Pharmacokinetic profile of diosgenin and trigonelline following intravenous and oral administration of fenugreek seed extract and pure compound in rabbit

Neda Mohamadi et al. J Asian Nat Prod Res. 2021 May.

Abstract

Diosgenin (DI) and trigonelline (TRG) are the main bioactive compounds of fenugreek seed. A micro-extraction method using magnetic nanocomposites coupled with ion-pairing reversed phase HPLC (RP-HPLC) method was used to determine the analytes in rabbit plasma. The main PK parameters after oral administration of pure DI and the extract were: Cmax: 0.48, 0.057 µg/ml; tmax: 1, 2 h; and t1/2β: 6.23, 15.04 h, respectively. Pure TRG and the extract PK parameters were: Cmax: 0.121, 0.081 µg/ml; tmax: 1.30, 1.30 h; and t1/2β: 20.06, 24.70 h, respectively. Generally, the PK profile of the two compounds was best fitted on the two-compartment model.[Formula: see text].

Keywords: magnetic nanoparticles; pharmacokinetics; Fenugreek; diosgenin; trigonelline.

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