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Review
. 2020 Nov;28(11):900-912.
doi: 10.1016/j.tim.2020.04.003. Epub 2020 May 21.

Role of Neutralizing Antibodies in CMV Infection: Implications for New Therapeutic Approaches

Virginia Sandonís  1 , Estéfani García-Ríos  2 , Michael J McConnell  2 , Pilar Pérez-Romero  3
Affiliations
Review

Role of Neutralizing Antibodies in CMV Infection: Implications for New Therapeutic Approaches

Virginia Sandonís et al. Trends Microbiol. 2020 Nov.

Abstract

Cytomegalovirus (CMV) infection elicits a potent immune response that includes the stimulation of antibodies with neutralizing activity. Recent studies have focused on elucidating the role of neutralizing antibodies in protecting against CMV infection and disease and characterizing viral antigens against which neutralizing antibodies are directed. Here, we provide a synthesis of recent data regarding the role of neutralizing antibodies in protection against CMV infection/disease. We consider the role of humoral immunity in the context of the global CMV-specific immune response, and the implications that recent findings have for vaccine and antibody-based therapy design.

Keywords: CMV-specific immune response; antibody-based therapeutics; cytomegalovirus; neutralizing antibodies; vaccine design.

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Conflict of interest statement

Disclaimer Statement M.J.M. and P.P.R. are founders and shareholders of Vaxdyn, S.L., a biotechnology company developing vaccines.

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