Regulation of the pentose phosphate cycle in bass (Dicentrarchus labrax L.) liver
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- PMID: 3244891
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Regulation of the pentose phosphate cycle in bass (Dicentrarchus labrax L.) liver
Rev Esp Fisiol.
1988 Dec.
Abstract
The influence in the activities of the glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase produced by the ratio changes NADPH/NADP is studied. The intracellular ratios of 20 and 10 are enough to achieve total inhibition of these two enzymes, respectively. Measurements of a number of metabolic intermediates show that the concentrations of Krebs cycle compounds are higher than those of glycolytic pathway metabolites. From a consideration of these values, the regulation of the pentose phosphate cycle mainly by the intracellular NADPH/NADP ratio, is discussed.
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